Diabetes mellitus is one of the more common maladies in today's society. Diabetes is often complicated by an affliction of the lower limbs, referred to as "the diabetic foot". One factor contributing to further complications is neuropathy, damage to the nerves of the lower limbs. This lack of sensitivity can lead to dry skin and a sweat formation on the feet. In cases of inadequate care of the feet, these changes may result in cracks appearing, minute skin lesions, a subsequent possibility of infection, or fungus (Athletes Foot). In many cases, this could result in an amputation of the afflicted part of the foot.

There is a possibility of reducing this risk by means of protecting the risky parts of the feet with appropriately selected footwear. Decreased blood supply to the feet and legs from narrowed and hardened blood vessels (Atherosclerosis), and high blood sugar levels (Hyperglycemia) which prevents normal healing, leading to infection, are other such risks.